>>> a remarkably busy news day getting busier this hour. i have breaking news to report. the reports of what is described as a major explosion at a burning fertilizer plant just north of waco, texas. this appears to have happened about an hour ago. the plant was already on fire when the explosion happened. a number of injuries have been reported and several buildings may be damaged or destroyed. people were trapped at a nearby nursing home or apartment building that may have been damaged by the explosion. a fertilizer plant near waco, texas. we're keeping a close eye on
বৃহস্পতিবার, ১৮ এপ্রিল, ২০১৩
মঙ্গলবার, ২ এপ্রিল, ২০১৩
YouTube bans Robin Thicke's video for nudity
Colin Young-Wolff / AP
By Us Weekly
Too hot to handle? Robin Thicke's latest music video for new single "Blurred Lines" may be blurring the line between artistic license and X-rated adult entertainment, according to critics of the video.
In the music video, the sultry singer is surrounded by several models who strip down over the course of the video, save for a few strategically placed farm animals and nude-colored panties.?
PHOTOS: Celebrity nude scandals
An unrated version of Thicke's video, with also features rappers T.I. and Pharrell (fully clothed), was pulled off YouTube shortly after its debut late last week, prompting the singer to tweet his disappointment.
"YouTube took down the Unrated version of #BLURREDLINES because it was toot!" he tweeted on Saturday, March 30.
Pharrell responded with similar disbelief: "Why?they trying to ban good sh--?"
(Note: Video below has no overt nudity, though it is sexually suggestive.)
PHOTOS: Hollywood's hottest married couples
At one point during the music video, the phrase "Robin Thicke Has a Big D" appears across the screen. The crooner's last name also flashes in bold red font numerous times throughout the length of the upbeat video.
Representatives for YouTube have thus far not commented on their removal of the video.
PHOTOS: Celebs and their soul mates
In an interview with the Associated Press, the 36-year-old singer explained that he got wife Paula Patton's permission before going forward with the videos.
"When I first got both videos, I liked them both, but I thought the first one is so good maybe we'll just release that and not release the second one," he said. "And then I started playing it for my friends and my lady, and everybody just thought it was great. It's entertainment ? Obviously if she (Patton) didn't like it, I wouldn't put it out."
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U.S. demand for skilled worker visas seen topping quota soon
SAN FRANCISCO (Reuters) - A popular U.S. visa program for skilled workers is likely to hit its quota within days after its application period opens, triggering a lottery and signaling that companies feel confident enough about the economy to hire more foreign workers.
The H-1B program will not have reached its base cap of 65,000 so quickly since early 2008, before the economic crisis hit. That was the last time a lottery was used, according to U.S. Citizenship and Immigration Services, which processes the applications.
The application period opened on Monday. The USCIS plans to announce by the middle of next week if it will hold a lottery for the visas, a spokesman told Reuters on Monday. It had previously said it anticipated the quota for the year starting October 1 could be met by Friday.
Last year the cap was not reached until June.
Preliminary paperwork that prospective visa seekers must file with the Department of Labor before applying to USCIS indicates that there is demand for well over 65,000 visas, said Jacksonville, Florida-based lawyer Ashwin Sharma, who handles H-1B visa applications for technology consulting firms. He expects a record volume of applications this year.
U.S. companies, particularly in technology, say they need the visas to fill vacant positions. But some worker-advocacy groups counter that the companies are using the visa program to hire cheaper foreign labor.
While the official quota is 65,000, the actual number of people who enter the United States on H-1Bs is far greater because workers at universities and some other workplaces don't count toward the limit. Masters and PhD graduates from U.S. universities have their own quota of 20,000 visas.
Last year, the government issued 129,000 H-1B visas - almost double level of the official quota.
The U.S. Congress is currently working on immigration reform legislation. Among proposals being considered is a revamp of the H-1B program that could raise the quota based on demand and eliminate the lottery.
(Reporting by Sarah McBride; Editing by Eric Walsh)
Source: http://news.yahoo.com/u-demand-skilled-worker-visas-seen-topping-quota-011854262.html
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Crucial step in human DNA replication observed for the first time
Apr. 1, 2013 ? For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human DNA replication is performed."
The results of the research will be published in the journal eLife on 2 April 2013.
Part of the DNA replication process -- in humans and in other life forms -- involves loading of molecular structures called sliding clamps onto DNA. This crucial step in DNA replication had remained somewhat mysterious and had not been well studied in human DNA replication. Mark Hedglin, a post-doctoral researcher in Penn State's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band. The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material. "Without a sliding clamp, polymerases can copy very few bases -- the molecular 'letters' that make up the code of DNA -- at a time. But the clamp helps the polymerase to stay in place, allowing it to copy thousands of bases before being removed from the strand of DNA," Hedglin said.
Hedglin explained that, due to the closed circular structure of sliding clamps, another necessary step in DNA replication is the presence of a "clamp loader," which acts to latch and unlatch the sliding clamps at key stages during the process. "The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin. "We know that polymerases and clamp loaders can't bind the sliding clamp at the same time, so the hypothesis was that clamp loaders latched sliding clamps onto DNA, then left for some time during DNA replication, returning only to unlatch the clamps after the polymerase left so they could be recycled for further use."
To test this hypothesis, the team of researchers used a method called F?rster resonance energy transfer (FRET), a technique of attaching fluorescent "tags" to human proteins and sections of DNA in order to monitor the interactions between them. "With these tags in place, we then observed the formation of holoenzymes -- the active form of the polymerase involved in DNA replication, which consists of the polymerase itself along with any accessory factors that optimize its activity," Hedglin said. "We found that whenever a sliding clamp is loaded onto a DNA template in the absence of polymerase, the clamp loader quickly removed the clamp so that free clamps did not build up on the DNA. However, whenever a polymerase was present, it captured the sliding clamp and the clamp loader then dissociated from the DNA strand."
The team members also found that, during the moments when both the clamp loader and the clamp were bound to the DNA, they were not intimately engaged with each other. Rather, the clamp loader released the closed clamp onto the DNA, allowing an opportunity for the polymerase to capture the clamp, completing the assembly of the holoenzyme. Subsequently, the clamp loader dissociated from DNA. "Our research demonstrates that the DNA polymerase holoenzyme in humans consists of only a clamp and a DNA polymerase. The clamp loader is not part of it. It disengages from the DNA after the polymerase binds the clamp," Hedglin added.
Benkovic noted that this mechanism provides a means for the cell to recycle scarce clamps when they are not in use for productive replication.
In addition to Benkovic and Hedglin, other Penn State researchers who contributed to the paper include Senthil K Perumal and Zhenxin Hu.
The research was funded by the National Institutes of Health.
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The above story is reprinted from materials provided by Penn State.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Mark Hedglin, Senthil K Perumal, Zhenxin Hu, Stephen Benkovic. Stepwise assembly of the human replicative polymerase holoenzyme. eLife, 2013; (in press) [link]
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/FJWArHcm-sM/130401151039.htm
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শুক্রবার, ৮ মার্চ, ২০১৩
Gardner Denver agrees to $3.73B sale
WAYNE, Pa. (AP) ? Industrial pump maker Gardner Denver said Friday that it has agreed to sell itself to Kohlberg Kravis Roberts & Co. for about $3.73 billion.
Under the terms of the agreement, the New York-based private equity firm will acquire the Wayne, Pa.-based company for $76 per share.
That represents a 3 percent premium over the company's Thursday closing stock price and a 39 percent premium over its closing stock price on Oct. 24, the day before it announced it was exploring a possible sale.
The companies valued the deal at $3.9 billion including the assumption of debt.
Gardner Denver said in October that it would be reviewing its "strategic options," which generally include a sale of all or part of a company. That came after the company's August announcement that it would restructure its business to improve its profitability by consolidating manufacturing facilities and cutting staff.
In recent weeks, Gardner Denver shares have jumped on media reports that KKR had made a bid for the company.
The deal has been approved by Gardner Denver's board, but remains subject to shareholder and regulatory approvals. It's expected to close in the third quarter.
Shares of Gardner Denver Inc. rose 86 cents to $74.71 in morning trading Friday.
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No Winning Exploit Found For Chrome OS At Annual Hacking Competition, Pwnium 3
Google's operating system Chrome OS survived all attempts to hack it at this year's?Pwnium 3 competition, which took place at the CanSecWest security conference in Vancouver, BC?this week. Google, which was offering up $3.14159 million in prize money (get it, Pi money?), said that there was no winning entry, but it was in the process of evaluating some exploits for partial credit.Source: http://feedproxy.google.com/~r/Techcrunch/~3/Iv_rc6BqVso/
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Google Tests Same-Day Delivery, Raising Marketplace Speculation ...
SAN FRANCISCO, United States ??Google Inc began testing a same-day delivery service with retailers in recent weeks, the latest move into Amazon.com Inc?s e-commerce turf by the world?s largest Internet search company.
Google Shopping Express helps local retail stores sell products online and have the items delivered to shoppers the same day, according to a person familiar with the test.
Google arranges for third parties, such as couriers, to pick the products up from local stores and deliver the items to shoppers. Neither the stores nor Google handle the deliveries, the person explained on condition of anonymity because the service is still in the early development stage.
Tom Fallows, a Google product management director with over a decade of e-commerce experience, is running Google Shopping Express. The test is focused on the San Francisco Bay Area and has been going for at least a month, the person added.
Google has not yet decided how to charge for the service. It is considering an annual subscription, similar to Amazon, which charges $79 a year for free two-day delivery of many items purchased on Amazon.com. However, Google may also charge a small fee each time a shopper orders through the service, the person said.
Google Shopping Express is the latest sign that the company is expanding from its online search roots into e-commerce. It also suggests that Google may be building an online marketplace that connects merchants and consumers, a business model that has made Amazon and eBay Inc successful in the United States.
?Google needs to become a marketplace,? said Scot Wingo, chief executive of ChannelAdvisor, which helps merchants sell more online. ?This is another step.? EBay is an investor in ChannelAdvisor.
Amazon?s marketplace business, which lets other merchants sell through its website, has grown rapidly in recent years and has been a big driver of Amazon?s revenue and profit growth.
This success has encouraged more shoppers to search for products on Amazon.com, rather than going to Google ? a potential threat to Google?s search dominance online.
In the past, consumers would search for an item on Google.com, an Amazon sponsored link would pop up, the shopper would click through, Google would get paid for the ad and Amazon got the sale.
?Everyone was happy. At least they used to be,? said Tom Allason, founder of Shutl, a startup that provides same-day delivery for retailers? online orders. ?Today Google needs a new play because increasingly consumers are cutting out Google and going direct to Amazon for their product search.?
Last year, Google changed its free product search offering to a paid service called Product Listing Ads, a move aimed at generating more revenue and profit from e-commerce.
In February, Google acquired Channel Intelligence, a $125 million deal that brought the search giant lots of data on e-commerce transactions. Longer-term, that could help Google build a product catalog, a crucial ingredient for an online marketplace that would compete with Amazon and eBay, according to Wingo.
?We view Google Shopping Express as another step in the evolution of Google Shopping and potential move to a full-blown marketplace,? Shawn Milne, an analyst at Janney Montgomery Scott, wrote in a note to investors on Tuesday.
Amazon has an advantage because it already has a network of large distribution warehouses, known as fulfillment centers, to deliver goods sold through its online marketplace, according to Wingo.
Google is likely taking a different approach, building a network of loosely affiliated local retail stores that, in effect, act like small fulfillment centers, Wingo explained.
EBay took a similar approach when it acquired Milo in late 2010. Milo let shoppers search for products available to buy in retail stores nearby.
The business formed the foundation of eBay?s Local Shopping business and is a crucial part of eBay Now, a same-day delivery service that the company began testing in San Francisco and New York last year.
(Reporting by Alistair Barr; Editing by Phil Berlowitz)
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বৃহস্পতিবার, ৭ মার্চ, ২০১৩
Suspect in deadly NYC crash ready to surrender
This undated photo, provided by the New York City Police Department on Monday March 4, 2013, shows Julio Acevedo, 44, who police are looking for in connection with the death of an expectant couple that was killed in a car accident in Brooklyn early Sunday morning and their premature baby, who was delivered alive but did not survive. Police are searching for the driver of a BMW who fled on foot after slamming into the livery cab transporting Nachman Glauber and his pregnant wife Raizy, both 21 years old. (AP Photo/NYPD)
This undated photo, provided by the New York City Police Department on Monday March 4, 2013, shows Julio Acevedo, 44, who police are looking for in connection with the death of an expectant couple that was killed in a car accident in Brooklyn early Sunday morning and their premature baby, who was delivered alive but did not survive. Police are searching for the driver of a BMW who fled on foot after slamming into the livery cab transporting Nachman Glauber and his pregnant wife Raizy, both 21 years old. (AP Photo/NYPD)
A person walks towards the graves of Nathan and Raizy Glauber, at the Satmar Cemetery 2 in Kiryas Joel, New York, Monday, March 4, 2013. The baby boy delivered prematurely after his parents, Nathan and Raizy Glauber, were killed Sunday in a New York City hit-and-run accident died Monday, March 4, 2013, a community spokesman said, while the search for the driver who fled on foot narrowed. (AP Photo/Craig Ruttle)
FILE - In this file photo of March 3, 2013, mourners surround a casket outside the Congregation Yetev Lev D'Satmar synagogue at the funeral for two expectant parents who were killed in a car accident early Sunday, in the Brooklyn borough of New York. The baby of Nachman and Raizy Glauber, a boy, was delivered prematurely cesarean section and survived until the next morning but died around 5:30 a.m. on Monday, March 4, 2013. Police were searching for the driver of a BMW and a passenger who fled on foot after slamming into the livery cab that transporting the 21-year-old couple to a hospital. (AP Photo/John Minchillo, File)
In this March 3, 2013, photo provided by VosIzNeias.com, Orthodox Jewish mourners gather outside the Congregation Yetev Lev D'Satmar synagogue in Brooklyn's Williamsburg neighborhood for the funeral of two expectant parents who were killed in a car accident early Sunday, in New York. The baby of Nachman and Raizy Glauber, a boy, was delivered prematurely by cesarean section and survived until the next morning, but died around 5:30 a.m. on Monday, March 4. Police were searching for the driver of a BMW and a passenger who fled on foot after slamming into the livery cab that was transporting the 21-year-old couple to a hospital. (AP Photo/VosIzNeias.com, Eli Wohl)
This undated photo, provided by the New York City Police Department on Monday March 4, 2013, shows Julio Acevedo, 44, who police are looking for in connection with the death of an expectant couple that was killed in a car accident in Brooklyn early Sunday morning and their premature baby, who was delivered alive but did not survive. Police are searching for the driver of a BMW and a passenger who fled on foot after slamming into the livery cab transporting Nachman Glauber and his pregnant wife Raizy, both 21 years old. (AP Photo/NYPD)
NEW YORK (AP) ? The suspected driver who fled the scene of a grisly crash that killed a pregnant woman, her husband and ultimately the child they were expecting said Tuesday that he planned to surrender, though police continued searching for him and said they would arrest him if they found him.
Julio Acevedo, 44, told the Daily News of New York that he was speeding away from a gunman who was trying to shoot at him early Sunday when the accident with a hired car happened in the Williamsburg section of Brooklyn.
He said he fled the scene because he was worried he'd be killed and didn't know the couple had died until he saw it in newspapers.
"My heart goes out to them," Acevedo told the newspaper Tuesday in a phone call arranged by a friend. "I didn't know they died until I saw the news."
The friend who arranged the call, Derrick Hamilton, said Acevedo was running for his life after the crash, and called it a terrible accident. "He's meeting with a lawyer right now, they are going to arrange how to turn himself in," Hamilton told The Associated Press.
Police said later Tuesday they had had no contact with Acevedo.
"We are still looking to apprehend him," spokesman Paul Browne said. "We have no information that he is going to surrender."
Acevedo was in a BMW going at least 60 mph when he crashed into another car carrying Nachman and Raizy Glauber, both 21. They died Sunday, and their premature son died Monday. The hired car had a stop sign; it's not clear if the driver stopped.
Acevedo was arrested last month on a charge of driving while under the influence, and the case is pending. He was stopped by police after they said he was driving erratically around 3 a.m. Feb. 17. He had a blood-alcohol level of .13, over the limit of .08, police said.
He served about a decade in prison in the 1990s for manslaughter after he was convicted of shooting Kelvin Martin, a Brooklyn criminal whose moniker "50 Cent" was the inspiration for rapper Curtis Jackson's current stage name. Neighbors said his mother lived in the same building, but she did not answer her door.
Shortly after midnight Sunday, Raizy Glauber, who was seven months pregnant, wasn't feeling well, so the couple decided to go to the hospital, said Sara Glauber, Nachman Glauber's cousin. They called a livery cab, a hired car that is arranged via telephone, not hailed off the street like a yellow cab.
The crash with the BMW reduced the cab to a crumpled heap, and Raizy Glauber was thrown from the wreck. The engine ended up in the back seat. The driver of the livery cab was knocked unconscious but was not seriously hurt.
The couple belonged to a close-knit ultra-Orthodox Jewish community in Brooklyn, which is home to the largest community of ultra-Orthodox Jews outside Israel, more than 250,000. They were members of the Satmar Hasidic sect. Raizy Glauber grew up in a prominent rabbinical family. Her husband was studying at a rabbinical college; his family founded a line of clothing for Orthodox Jews.
The child was delivered by cesarean section after his parents were killed. The baby weighed only about 4 pounds when he was delivered, neighbors and friends said. He died of extreme prematurity, the city medical examiner's office said.
The baby was buried Monday near the fresh graves of his parents, according to Isaac Abraham, a spokesman for the Hasidic Jewish community. About a thousand community members turned out for the young couple's funeral a day earlier. They offered $15,000 reward for information leading to Acevedo's capture and called for murder charges to be filed.
How Acevedo came to possess the BMW is under investigation. The registered owner, Takia Walker, was arrested Sunday on insurance fraud charges in a scam involving the car, police said, but the Bronx district attorney's office said Tuesday that the case was deferred. Walker was not involved in the crash. A telephone number listed for her rang unanswered.
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Major Development In WWE Creative - WrestlingInc.com
Former WWE executive Court Bauer (@CourtBauer) sent me a message moments ago that Eric Pankowski is out as Senior Vice President of Creative and Development at WWE.
Pankowski was hired in February of last year. He was reporting to Stephanie McMahon, and was responsible for the creative development of television content, managing WWE's creative writing teams and selling programming.
Speaking of Court, the latest episode of Wrestling Inc. Weekly with Court and myself is now available on iTunes at this link. In this week's episode, Court and I discuss Paul Bearer's passing, The Rock vs. John Cena not generating interest, The Undertaker's return, the build-up for WrestleMania so far, why managers should be brought back, Ric Flair and more.
Got a news tip or correction? Send it to us by clicking here.
Source: http://www.wrestlinginc.com/wi/news/2013/0307/560950/major-development-in-wwe-creative/
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College hoops season filled with surprises
College hoops season filled with surprises
By JOHN MARSHALLBy JOHN MARSHALL, AP Basketball Writer?
?FILE - In this Jan. 23, 2013, file photo, Miami's Durand Scott celebrates their 90-63 win over Duke in an NCAA college basketball game in Coral Gables, Fla. In a season of parity that has produced quite a few surprises, a few of the unexpected turns, such as Miami's success, have stood out. (AP Photo/Alan Diaz, File)
FILE - In this Jan. 23, 2013, file photo, Miami's Durand Scott celebrates their 90-63 win over Duke in an NCAA college basketball game in Coral Gables, Fla. In a season of parity that has produced quite a few surprises, a few of the unexpected turns, such as Miami's success, have stood out. (AP Photo/Alan Diaz, File)
FILE - In this Feb. 5, 2013, file photo, Akron's Zeke Marshall (44) celebrates a play with Chauncey Gilliam (23) in an NCAA college basketball game against Central Michigan in Akron, Ohio. InIn a season of parity that has produced quite a few surprises, a few of the unexpected turns, such as Akron's success, have stood out. (AP Photo/Mark Duncan, File)
FILE - In this Jan. 26, 2013, file photo, Oregon forward E.J. Singler (25) runs downcourt past head coach Dana Altman and the bench, including guard Damyean Dotson (21) and center Tony Woods (55), after hitting a 3-pointer against Washington in an NCAA college basketball game in Eugene, Ore. In a season of parity that has produced quite a few surprises, a few of the unexpected turns, such as Oregon's success, have stood out. (AP Photo/Chris Pietsch, File)
FILE - In this Dec. 21, 2012, file photo, Middle Tennessee guard Marcos Knight (14) celebrates after drawing a foul in the final seconds of an NCAA college basketball game against Vanderbilt in Nashville, Tenn. In a season of parity that has produced quite a few surprises, a few of the unexpected turns, such as Middle Tennessee's success, have stood out. (AP Photo/Mark Humphrey, File)
FILE - In this Feb. 22, 2013, file photo, Saint Louis' Rob Loe (51) celebrates after their 65-61 win over Butler in an NCAA college basketball game in Indianapolis. In a season of parity that has produced quite a few surprises, a few of the unexpected turns, such as Saint Louis' success, have stood out. (AP Photo/Doug McSchooler, File)
This season of parity in college basketball has produced quite a few surprises, from the revolving door at the top of the polls to the rapid decline of defending national champion Kentucky.
The latest twist came this week, when Gonzaga moved up to No. 1 for the first time in school history. That was merely a mild surprise. The Zags have been the pre-eminent mid-major for what feels like a quarter century now, so it only seemed like a matter of time before they went to No. 1.
Some of the other unexpected turns have been, well, a little more unexpected. Here's a few:
___
Miami. The Hurricanes were ranked fifth in the ACC preseason poll and even though they returned nine players from a 20-win team, weren't expected to draw much attention in South Florida ? or anywhere else for that matter. Miami had a look-at-us moment on Jan. 23 when it beat Duke by 27 ? the third-largest margin of victory over a No. 1 team ? and cracked the Top 25 the next week. The Hurricanes continued to build momentum, winning their first 13 conference games to rise in The Associated Press poll. Miami has struggled a bit lately, losing three of its past four ? by two to Georgia Tech Wednesday night ? but has already clinched a share of the ACC regular-season title and can win its first outright conference title by beating Clemson on Saturday.
___
Akron. Coach Keith Dambrot has given the Zips an identity in Ohio and the Mid-American Conference, but it hasn't gone much farther. That changed this season as Akron ran off 19 straight wins, shining a spotlight on a town better known for being the home of LeBron James. The Zips had their winning streak ? the longest in the nation at the time ? end with a loss to Buffalo last Saturday, but bounced back to beat Miami (Ohio) Tuesday night and wrap up their second consecutive Mid-American Conference regular-season title. And with a good mix of size, strength and experience, Akron (24-5, 14-1) has the kind of team that could damage a few brackets once the NCAA tournament rolls around.
___
Oregon. The Ducks played in the NIT last season and entered this season with nine newcomers, including seven freshmen, so it was no surprise they were picked to finish seventh in the Pac-12. Behind guard E.J. Singler and one of the most balanced teams anywhere, Oregon opened 11-2 in nonconference, then knocked off Pac-12 favorites Arizona and UCLA to rise in the polls. The Ducks slipped up with three straight losses, but have won five of six to take a half-game lead over UCLA atop the Pac-12. Heading into the final two games of the regular season, Oregon (23-6, 12-4) has a chance to win its first conference title since 2002 and is close to wrapping up its first NCAA tournament berth in five years.
___
Middle Tennessee. The Blue Raiders appeared to be a lock for the NCAA tournament last season before losses in the regular-season finale and quarterfinals of the Sun Belt Conference tournament relegated them to the NIT. They may be closer to a sure thing this season. Led by six seniors, Middle Tennessee set a school record with 27 wins, second nationally to No. 1 Gonzaga, and has an RPI of 25 after playing the nation's ninth-toughest schedule. The Blue Raiders went 19-1 in the Sun Belt and have won 16 straight headed into Saturday's conference tournament, their last before heading to Conference USA next season. Barring a meltdown in the conference tournament, Middle Tennessee (27-4) should be headed to the NCAA tournament for the first time since 1989.
___
Saint Louis. The Billikens ended a 12-year NCAA tournament drought last year, but were rocked by the death of former coach Rick Majerus. The 64-year-old coach took a leave of absence in August and died of a heart attack in December, a month after the school said he would not return. That left the team reeling and in the hands of interim coach Jim Crews. Behind a stifling defense, Saint Louis has done just fine under Crews, going 4-1 against ranked teams, with wins over Virginia Commonwealth and New Mexico, and two over Butler. The 16th-ranked Billikens (23-6) had their 11-game winning streak ended by Xavier on Wednesday night, but can still clinch a piece of the Atlantic 10 crown ? their first league title since 1970-71 in the Missouri Valley ? by beating LaSalle on Saturday.
___
Louisiana Tech. The Bulldogs were barely .500 last season, finished fifth in the WAC and lost key players, so there was no reason to think an NCAA berth would be coming. Louisiana Tech opened the season with a loss to Texas A&M and opened December with losses to Northwestern State and McNeese State in a span of three games. Once the WAC season started, though, the Bulldogs became unstoppable. Heading into Thursday's regular-season finale against New Mexico State, Louisiana Tech has won 18 straight for the nation's longest winning streak. The Bulldogs (26-3) are undefeated in conference (16-0) and have clinched at least a share of their first conference title since the Sun Belt in 1999. Not bad for their second season under coach Michael White.
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Progenics Pharmaceuticals' Novel Small Molecule Drugs Targeting ...
? Positive Data Reported in The Journal of Nuclear Medicine ?
? Global Phase 2 Imaging Trial of Next Generation Molecule Underway ?
TARRYTOWN, N.Y., March 5, 2013 (GLOBE NEWSWIRE) -- Progenics Pharmaceuticals, Inc. (Nasdaq:PGNX) reported positive clinical data from a study of two novel radiolabeled small molecules targeting prostate-specific membrane antigen (PSMA). The imaging agents ? 123I-MIP-1072 and 123I-MIP-1095 ? had a high sensitivity of lesion detection in bone, tissue and the prostate gland with minimal retention in non-target tissue. The research was published as the cover article in the March issue of The Journal of Nuclear Medicine.
"Existing imaging techniques are limited in their ability to diagnose and stage prostate cancer," said John J. Babich, Ph.D., senior author of the article "First-in-Man Evaluation of Two High-Affinity PSMA-Avid Small Molecules for Imaging Prostate Cancer." "The approach described in this paper has the potential to assess disease status more accurately. It could help clinicians select optimal treatments and lead to better patient outcomes."
Separate phase 1 studies were conducted under an exploratory investigational new drug (IND) application to measure the potential effectiveness of the small molecules in diagnosing and staging prostate cancer. In the first study, seven patients with documented prostate cancer were administered doses of 123I-MIP-1072 and 123I-MIP-1095, two weeks apart. In the second study, six healthy volunteers received 123I-MIP-1072 only. Whole body planar imaging and single photon emission computed tomography (SPECT)/computed tomography (CT) were performed for each group, and pharmacokinetics, tissue distribution, excretion, safety and organ radiation dose were analyzed.
Based on the data reported, Progenics is conductinga global, multi-center phase 2 trial investigating a next generation radiolabeled small molecule targeting PSMA, MIP-1404.
Mark R. Baker, chief executive officer of Progenics, said, "We recently acquired all of the rights to the compounds described in this Journal of Nuclear Medicine paper, as well as to the phase 2 stage imaging agent MIP-1404, through Progenics' acquisition of Molecular Insight Pharmaceuticals. It is gratifying to see this expansion of our oncology pipeline demonstrating progress so soon."
Robert J. Israel, M.D., Progenics' senior vice president of medical affairs and clinical research, said, "We believe that MIP-1404 has excellent potential as a diagnostic radiopharmaceutical. Results to date from the study compounds and MIP-1404 show PSMA as a robust target for prostate cancer molecular imaging, and that a radiolabeled small molecule, which binds PSMA with high affinity, has the potential to detect prostate cancer throughout the body. Cancer treatment guidelines call for imaging prostate cancer with conventional bone scans or MRI. A more accurate method of imaging prostate cancer could be of great value."
Mr. Baker further added, "Thought leaders in prostate cancer care are focused on avoiding unnecessary surgery and other invasive procedures due to the complications associated with them. Clinicians generally prefer "watchful waiting" when the cancer appears to be indolent. At the same time, some therapeutics to treat aggressive prostate cancer have recently been approved or are under development, such as Progenics' own PSMA ADC, which currently is in phase 2 testing. Patients and their physicians would benefit from feedback on how therapeutic agents are impacting the course of cancer, and guidance on how and when to use therapeutic agents. It is clear that an improved way to visualize prostate cancer, with a high degree of specificity and sensitivity, would better inform both "watchful waiting" and the treatment of aggressive disease. We believe that data from the ongoing phase 2 trial of MIP-1404 will demonstrate its capabilities to assist prostate cancer patients and their physicians in making these critical decisions."
About Prostate Cancer
Prostate cancer is the most common form of cancer affecting men in the United States and is the second leading cause of cancer deaths among men each year. The American Cancer Society estimates that in 2013, 238,590 new cases of prostate cancer will be diagnosed and approximately 29,720 American men will die from the disease. Accurate diagnosis and staging of prostate cancer is critical to determining appropriate patient management.
About Progenics
Progenics Pharmaceuticals, Inc. is discovering and developing innovative medicines for oncology, with a pipeline that includes product candidates in preclinical through late-stage development. Progenics' first commercial product, Relistor? (methylnaltrexone bromide) for opioid-induced constipation, is marketed and in further development by Salix Pharmaceuticals, Ltd. for markets worldwide other than Japan, where Ono Pharmaceutical Co., Ltd. holds an exclusive license for the subcutaneous formulation. For additional information, please visit www.progenics.com.
The Progenics Pharmaceuticals Inc. logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=9678
This press release may contain projections and other forward-looking statements regarding future events. Such statements are predictions only, and are subject to risks and uncertainties that could cause actual events or results to differ materially. These risks and uncertainties include, among others, the cost, timing and results of clinical trials and other development activities; the unpredictability of the duration and results of regulatory review of New Drug Applications and Investigational NDAs; market acceptance for approved products; generic and other competition; the possible impairment of, inability to obtain and costs of obtaining intellectual property rights; and possible safety or efficacy concerns, general business, financial and accounting matters, litigation and other risks. More information concerning Progenics and such risks and uncertainties is available on its website, and in its press releases and reports it files with the U.S. Securities and Exchange Commission. Progenics is providing the information in this press release as of its date and does not undertake any obligation to update or revise it, whether as a result of new information, future events or circumstances or otherwise.
Additional information concerning Progenics and its business may be available in press releases or other public announcements and public filings made after this release.
(PGNX-C)
CONTACT: Kathleen Fredriksen
Corporate Development
(914) 789-2871
?
Posted: March 2013
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