>>> a remarkably busy news day getting busier this hour. i have breaking news to report. the reports of what is described as a major explosion at a burning fertilizer plant just north of waco, texas. this appears to have happened about an hour ago. the plant was already on fire when the explosion happened. a number of injuries have been reported and several buildings may be damaged or destroyed. people were trapped at a nearby nursing home or apartment building that may have been damaged by the explosion. a fertilizer plant near waco, texas. we're keeping a close eye on
বৃহস্পতিবার, ১৮ এপ্রিল, ২০১৩
মঙ্গলবার, ২ এপ্রিল, ২০১৩
YouTube bans Robin Thicke's video for nudity
Colin Young-Wolff / AP
By Us Weekly
Too hot to handle? Robin Thicke's latest music video for new single "Blurred Lines" may be blurring the line between artistic license and X-rated adult entertainment, according to critics of the video.
In the music video, the sultry singer is surrounded by several models who strip down over the course of the video, save for a few strategically placed farm animals and nude-colored panties.?
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An unrated version of Thicke's video, with also features rappers T.I. and Pharrell (fully clothed), was pulled off YouTube shortly after its debut late last week, prompting the singer to tweet his disappointment.
"YouTube took down the Unrated version of #BLURREDLINES because it was toot!" he tweeted on Saturday, March 30.
Pharrell responded with similar disbelief: "Why?they trying to ban good sh--?"
(Note: Video below has no overt nudity, though it is sexually suggestive.)
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At one point during the music video, the phrase "Robin Thicke Has a Big D" appears across the screen. The crooner's last name also flashes in bold red font numerous times throughout the length of the upbeat video.
Representatives for YouTube have thus far not commented on their removal of the video.
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In an interview with the Associated Press, the 36-year-old singer explained that he got wife Paula Patton's permission before going forward with the videos.
"When I first got both videos, I liked them both, but I thought the first one is so good maybe we'll just release that and not release the second one," he said. "And then I started playing it for my friends and my lady, and everybody just thought it was great. It's entertainment ? Obviously if she (Patton) didn't like it, I wouldn't put it out."
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U.S. demand for skilled worker visas seen topping quota soon
SAN FRANCISCO (Reuters) - A popular U.S. visa program for skilled workers is likely to hit its quota within days after its application period opens, triggering a lottery and signaling that companies feel confident enough about the economy to hire more foreign workers.
The H-1B program will not have reached its base cap of 65,000 so quickly since early 2008, before the economic crisis hit. That was the last time a lottery was used, according to U.S. Citizenship and Immigration Services, which processes the applications.
The application period opened on Monday. The USCIS plans to announce by the middle of next week if it will hold a lottery for the visas, a spokesman told Reuters on Monday. It had previously said it anticipated the quota for the year starting October 1 could be met by Friday.
Last year the cap was not reached until June.
Preliminary paperwork that prospective visa seekers must file with the Department of Labor before applying to USCIS indicates that there is demand for well over 65,000 visas, said Jacksonville, Florida-based lawyer Ashwin Sharma, who handles H-1B visa applications for technology consulting firms. He expects a record volume of applications this year.
U.S. companies, particularly in technology, say they need the visas to fill vacant positions. But some worker-advocacy groups counter that the companies are using the visa program to hire cheaper foreign labor.
While the official quota is 65,000, the actual number of people who enter the United States on H-1Bs is far greater because workers at universities and some other workplaces don't count toward the limit. Masters and PhD graduates from U.S. universities have their own quota of 20,000 visas.
Last year, the government issued 129,000 H-1B visas - almost double level of the official quota.
The U.S. Congress is currently working on immigration reform legislation. Among proposals being considered is a revamp of the H-1B program that could raise the quota based on demand and eliminate the lottery.
(Reporting by Sarah McBride; Editing by Eric Walsh)
Source: http://news.yahoo.com/u-demand-skilled-worker-visas-seen-topping-quota-011854262.html
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Crucial step in human DNA replication observed for the first time
Apr. 1, 2013 ? For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human DNA replication is performed."
The results of the research will be published in the journal eLife on 2 April 2013.
Part of the DNA replication process -- in humans and in other life forms -- involves loading of molecular structures called sliding clamps onto DNA. This crucial step in DNA replication had remained somewhat mysterious and had not been well studied in human DNA replication. Mark Hedglin, a post-doctoral researcher in Penn State's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band. The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material. "Without a sliding clamp, polymerases can copy very few bases -- the molecular 'letters' that make up the code of DNA -- at a time. But the clamp helps the polymerase to stay in place, allowing it to copy thousands of bases before being removed from the strand of DNA," Hedglin said.
Hedglin explained that, due to the closed circular structure of sliding clamps, another necessary step in DNA replication is the presence of a "clamp loader," which acts to latch and unlatch the sliding clamps at key stages during the process. "The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin. "We know that polymerases and clamp loaders can't bind the sliding clamp at the same time, so the hypothesis was that clamp loaders latched sliding clamps onto DNA, then left for some time during DNA replication, returning only to unlatch the clamps after the polymerase left so they could be recycled for further use."
To test this hypothesis, the team of researchers used a method called F?rster resonance energy transfer (FRET), a technique of attaching fluorescent "tags" to human proteins and sections of DNA in order to monitor the interactions between them. "With these tags in place, we then observed the formation of holoenzymes -- the active form of the polymerase involved in DNA replication, which consists of the polymerase itself along with any accessory factors that optimize its activity," Hedglin said. "We found that whenever a sliding clamp is loaded onto a DNA template in the absence of polymerase, the clamp loader quickly removed the clamp so that free clamps did not build up on the DNA. However, whenever a polymerase was present, it captured the sliding clamp and the clamp loader then dissociated from the DNA strand."
The team members also found that, during the moments when both the clamp loader and the clamp were bound to the DNA, they were not intimately engaged with each other. Rather, the clamp loader released the closed clamp onto the DNA, allowing an opportunity for the polymerase to capture the clamp, completing the assembly of the holoenzyme. Subsequently, the clamp loader dissociated from DNA. "Our research demonstrates that the DNA polymerase holoenzyme in humans consists of only a clamp and a DNA polymerase. The clamp loader is not part of it. It disengages from the DNA after the polymerase binds the clamp," Hedglin added.
Benkovic noted that this mechanism provides a means for the cell to recycle scarce clamps when they are not in use for productive replication.
In addition to Benkovic and Hedglin, other Penn State researchers who contributed to the paper include Senthil K Perumal and Zhenxin Hu.
The research was funded by the National Institutes of Health.
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The above story is reprinted from materials provided by Penn State.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Mark Hedglin, Senthil K Perumal, Zhenxin Hu, Stephen Benkovic. Stepwise assembly of the human replicative polymerase holoenzyme. eLife, 2013; (in press) [link]
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/FJWArHcm-sM/130401151039.htm
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